• The association of grip strength from midlife onwards with all-cause and cause-specific mortality over 17 years of follow-up in the Tromsø Study 

      Strand, Bjørn Heine; Cooper, Rachel; Bergland, Astrid; Jørgensen, Lone; Schirmer, Henrik; Skirbekk, Vegard; Emaus, Nina (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-25)
      <b>Background</b> Grip strength has consistently been found to predict all-cause mortality rates. However, few studies have examined cause-speci fi c mortality or tested age differences in these associations. <b>Methods</b> In 1994, grip strength was measured in the population-based Tromsø Study, covering the ages 50 – 80 years (N=6850). Grip strength was categorised into fi fths, and ...
    • Bone mineral density at the hip and its relation to fat mass and lean mass in adolescents: the Tromsø Study, Fit Futures 

      Winther, Anne; Jørgensen, Lone; Ahmed, Luai A.; Christoffersen, Tore; Furberg, Anne-Sofie; Grimnes, Guri; Jorde, Rolf; Nilsen, Ole-Andreas; Dennison, Elaine M.; Emaus, Nina (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-19)
      <p><i>Background</i>: Positive association between body weight and bone mass is well established, and the concept of body mass index (BMI) is associated with higher areal bone mineral density (aBMD) and reduced fracture risk. BMI, that comprises both fat mass (FM) and lean mass (LM) may contribute to peak bone mass achievement in different ways. This study explored the influence of body composition ...
    • Burden of hip fracture using disability-adjusted life-years: a pooled analysis of prospective cohorts in the CHANCES consortium 

      Papadimitriou, Nikos; Tsilidis, Konstantinos K.; Orfanos, Philippos; Benetou, Vassiliki; Ntzani, Evangelia E.; Soerjomataram, Isabelle; Künn-Nelen, Annemarie; Pettersson-Kymmer, Ulrika; Eriksson, Sture; Brenner, Hermann; Schöttker, Ben; Saum, Kai-Uwe; Holleczek, Bernd; Grodstein, Francine D.; Feskanich, Diane; Orsini, Nicola; Wolk, Alicja; Bellavia, Andrea; Wilsgaard, Tom; Jørgensen, Lone; Boffetta, Paolo; Trichopoulos, Dimitrios; Trichopoulou, Antonia (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-11)
      <p><i>Background</i>: No studies have estimated disability-adjusted life-years (DALYs) lost due to hip fractures using real-life follow-up cohort data. We aimed to quantify the burden of disease due to incident hip fracture using DALYs in prospective cohorts in the CHANCES consortium, and to calculate population attributable fractions based on DALYs for specific risk factors.</p> <p><i>Methods</i>: ...
    • Can vitamin D-3 supplementation prevent bone loss in persons with MS? A placebo-controlled trial 

      Steffensen, Linn Hofsøy; Jørgensen, Lone; Straume, Bjørn; Mellgren, Svein Ivar; Kampman, Margitta Theodora (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Multiple sclerosis (MS) is a possible cause of secondary osteoporosis. In this phase II trial we assessed whether a weekly dose of 20,000 IU vitamin D3 prevents bone loss in ambulatory persons with MS age 18–50 years. ClinicalTrials.gov ID NCT00785473. All patients managed at the University Hospital of North Norway who fulfilled the main inclusion criteria were invited to participate in this ...
    • Do More Recent Born Generations of Older Adults Have Stronger Grip? A Comparison of Three Cohorts of 66- to 84-Year-Olds in the Tromsø Study 

      Strand, Bjørn Heine; Bergland, Astrid; Jørgensen, Lone; Schirmer, Henrik; Emaus, Nina; Cooper, Rachel (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-11)
      <p><i>Background</i>: Evidence pertaining to whether more recent born generations of adults reaching old age have better physical capability than previous generations is scarce and inconclusive. We aimed to investigate birth cohort differences in grip strength.</p> <p><i>Methods</i>: The study comprised 5,595 individuals from the Tromsø study waves in 1994/1995, 2007/2008, and 2015/2016. Grip ...
    • Dynamic balance and gait speed improve in persons with Parkinson's disease after Lee Silverman Voice Treatment (LSVT)-BIG training: a single subject experimental design study 

      Kleppang, Tale Tangen; Jørgensen, Lone (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-30)
      <i>Background</i>: Parkinson ́s disease (PD) is characterised by small, slow movements affecting balance and gait. Lee-Silverman-Voice-Treatment-(LSVT)-BIG is an intensive intervention aiming to restore normal amplitudes of movements. This study aimed to examine whether LSVT-BIG influences dynamic balance and gait in persons with PD.<p> <p><i>Methods</i>: We used a Single-Subject-Experimental-Design ...
    • Effects of a parent-administered exercise program in the neonatal intensive care unit: Dose does matter-a randomized controlled trial 

      Øberg, Gunn Kristin; Girolami, Gay L; Campell, Suzann K.; Ustad, Tordis; Heuch, Ivar; Jacobsen, Bjarne K.; Kaaresen, Per Ivar; Aulie, Vibeke Smith; Jørgensen, Lone (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-06)
      Background - Despite the risk of delayed motor development in infants born preterm, knowledge about interventions in the neonatal intensive care unitt (NICU) and the effects of dosing is sparse. <p> <p>Objective - The objectives of this study were to examine the effectiveness of a parent-administered exercise program in the NICU on motor outcome at 3 months corrected age (CA) and the effect of ...
    • External Validation of the Garvan Nomograms for Predicting Absolute Fracture Risk: The Tromsø Study 

      Ahmed, Luai Awad; Nguyen, ND; Bjørnerem, Åshild; Joakimsen, Ragnar Martin; Jørgensen, Lone; Størmer, Jan; Bliuc, D; Center, Jacqueline R; Eisman, John; Nguyen, Tuan; Emaus, Nina (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
    • Fragile bones in patients with stroke? : bone mineral density in acute stroke patients and changes during one year of follow up 

      Jørgensen, Lone (Doctoral thesis; Doktorgradsavhandling, 2001)
      This thesis highlights several clinically important questions related to bone loss the first year following stroke and with regard to bone mass at stroke onset:<br> Lack of mobility and weight bearing early after stroke is an important factor for the greater bone loss in the proximal femur on the paretic side. Relearning to walk within the first two month after stroke, even with support of another ...
    • Impact of Osteoporotic Fracture Type and Subsequent Fracture on Mortality: The Tromsø Study 

      Alarkawi, Dunia; Bluic, Dana; Tran, T; Ahmed, Luai A; Emaus, Nina; Bjørnerem, Åshild; Jørgensen, Lone; Cristoffersen, T.; Eisman, JA; Center, JR (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-26)
      <i>Summary</i> - Less is known about the impact of non-hip non-vertebral fractures (NHNV) on early death. This study demonstrated increased risk of dying following hip and NHNV fractures which was further increased by a subsequent fracture. This highlights the importance of early intervention to prevent both initial and subsequent fractures and improve survival.<p> <p><i>Introduction</i> - ...
    • The independent and joint associations of physical activity and body mass index with myocardial infarction: The Tromsø Study 

      Renninger, Marius; Løchen, Maja-Lisa; Ekelund, Ulf; Hopstock, Laila Arnesdatter; Jørgensen, Lone; Mathiesen, Ellisiv B.; Njølstad, Inger; Schirmer, Henrik; Wilsgaard, Tom; Morseth, Bente (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-13)
      Physical activity and overweight are associated with myocardial infarction (MI). However, their joint association with MI remains unclear. Our objective was to examine the independent and joint association between leisuretime physical activity (LTPA), body mass index (BMI) and MI. This prospective cohort study included 16,572 men and women (47.5% women) aged 20–54 years who took part in the second ...
    • Leisure time physical activity and risk of non-vertebral fracture in men and women aged 55 years and older : the Tromso Study 

      Morseth, Bente; Ahmed, Luai A.; Bjørnerem, Åshild; Emaus, Nina; Jacobsen, Bjarne Koster; Joakimsen, Ragnar Martin; Størmer, Jan; Wilsgaard, Tom; Jørgensen, Lone (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Our aim was to examine associations between leisure time physical activity and risk of non-vertebral fractures in men and women aged ≥55 years, with focus on the anatomical fracture location. Self-reported physical activity was registered in 3,450 men and 4,072 women aged 55–97 years at baseline in the Tromsø Study, Norway, in 1994–1995. Non-vertebral fractures were registered through December 31, ...
    • Manually assisted body-weight supported locomotor training does not re-establish walking in non-walking subjects with chronic incomplete spinal cord injury: A randomized clinical trial 

      Piira, Anu Mirjam; Lannem, Anne M.; Sørensen, Marit; Glott, Thomas; Knutsen, Raymond; Jørgensen, Lone; Gjesdal, Knut; Hjeltnes, Nils; Knutsen, Synnøve Fønnebø (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-28)
      <p><i>Objective - </i>To assess the effects of manually assisted body-weight supported locomotor training in subjects with chronic incomplete spinal cord injury. <p><i>Design - </i>Randomized controlled clinical trial. <p><i>Subjects - </i>Twenty subjects with American Spinal Injury Association Impairment Scale grades C or D and > 2 years post-injury. <p><i>Methods - </i>Random allocation to 60 ...
    • Mobility as a predictor of all-cause mortality in older men and women: 11.8 year follow-up in the Tromso study 

      Bergland, Astrid; Jørgensen, Lone; Emaus, Nina; Strand, Bjørn Heine (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-01-10)
      Background: Disability in older adults is associated with loss of independence, institutionalization, and death. The aim of this study was to study the association between the Timed Up and Go (TUG) test and all-cause mortality in a population-based sample of older men and women. <p> Methods: Our study population was home dwellers aged 65 and above, who participated in the fifth wave of the Tromsø ...
    • The phosphodiesterase 8B gene rs4704397 is associated with thyroid function, risk of myocardial infarction and body height. The Tromsø Study 

      Jorde, Rolf; Schirmer, Henrik; Wilsgaard, Tom; Joakimsen, Ragnar Martin; Mathiesen, Ellisiv B.; Njølstad, Inger; Løchen, Maja-Lisa; Figenschau, Yngve Anton; Svartberg, Johan; Hutchinson, Moira Strand; Kjærgaard, Marie; Jørgensen, Lone; Grimnes, Guri (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Objective: High serum thyrotropin (TSH) levels predict cardiovascular disease (CVD). Recently several single nucleotide polymorphisms (SNPs) associated with TSH levels have been identified, one of them being the rs4704397 SNP in the phosphodiesterase 8B (PDE8B) gene. If the relation between thyroid function and CVD is causal, one could also expect rs4704397 genotypes to predict CVD and possibly ...
    • Physical activity and bone : the importance of the various mechanical stimuli for bone mineral density : a review 

      Morseth, Bente; Emaus, Nina; Jørgensen, Lone (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Numerous studies have reported benefits of regular physical activity on bone mineral density (BMD). The effects of physical activity on BMD are primarily linked to the mechanisms of mechanical loading, but the understanding of the precise mechanism behind the association is incomplete. The aim of this paper was to review the main findings concerning sources and types of mechanical stimuli in relation ...
    • Physical activity, resting heart rate, and atrial fibrillation: the Tromsø Study 

      Morseth, Bente; Graff-Iversen, Sidsel; Jacobsen, Bjarne K.; Jørgensen, Lone; Nyrnes, Audhild; Thelle, Dag Steinar; Vestergaard, Peter; Løchen, Maja-Lisa (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-03-10)
      Aims: The objective was to examine the association of physical activity and resting heart rate (RHR) with hospital-diagnosed atrial fibrillation (AF) in a Norwegian cohort. <p> Methods and Results: This prospective study included 20 484 adults (50.3% men) who participated in the third Tromsø Study survey in 1986-1987. At baseline, physical activity was assessed by a validated questionnaire, and ...
    • The Postural Assessment Scale for Stroke Patients: translation into Norwegian, cultural adaptation, and examination of reliability 

      Breistein, Karen; Gjelsvik, Bente E Bassøe; Jørgensen, Lone (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-06)
      Background: To translate the Modified Swedish version of Postural Assessment Scale for Stroke (SwePASS) into Norwegian (SwePASS-NV) and assess its intra- and interrater reliability. <br> <br> Methods: Translation and cross-cultural adaptation was accomplished according to international guidelines. Forty-seven adults, suffering a stroke within the last six months, were strategically recruited and ...
    • Robot-assisted locomotor training did not improve walking function in patients with chronic incomplete spinal cord injury: A randomized clinical trial 

      Piira, Anu Mirjam; Lannem, Anne M.; Sørensen, Marit; Glott, Thomas; Knutsen, Raymond; Jørgensen, Lone; Gjesdal, Knut; Hjeltnes, Nils; Knutsen, Synnøve Fønnebø (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-21)
      <p><i>Objective - </i>To assess the effects of robot-assisted locomotor training in patients with chronic incomplete spinal cord injury. <p><i>Design - </i>Randomized single-blind controlled clinical trial. <p><i>Setting - </i>The intervention site was an outpatient clinic, and pre- and post-evaluations were performed in a rehabilitation hospital. <p><i>Patients - </i>A total of 24 subjects with ...
    • Secular trends and correlates of physical activity: The Tromsø Study 1979-2008 

      Morseth, Bente; Jacobsen, Bjarne K.; Emaus, Nina; Wilsgaard, Tom; Jørgensen, Lone (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-03)
      <b>Background: </b>The aim was to describe secular trends in leisure time physical activity (LTPA) and work related physical activity (WPA) from 1979 to 2008. Additionally, we explored potential cross-sectional and longitudinal correlates of LTPA and WPA.<br> <b>Methods:</b> Data are collected from 34,898 individuals (49.7% men) aged >20 years who participated in at least one Tromsø Study survey ...